MOTS-c Peptide

Product Overview

MOTS-c is a mitochondria-derived research peptide composed of 16 amino acids and is widely studied for its potential role in metabolic regulation, energy balance, and cellular stress response. As one of the better-known mitochondrial-derived peptides, MOTS-c has attracted substantial scientific interest for its possible function as both an intracellular signaling molecule and a circulating metabolic regulator.

Because of its connection to mitochondrial communication and whole-cell energy control, MOTS-c is frequently examined in laboratory settings involving muscle metabolism, glucose regulation, fat metabolism, and age-related cellular function.

Research Profile

MOTS-c is frequently studied for its potential involvement in:

• metabolic homeostasis
• AMPK-related signaling
• glucose utilization
• lipid metabolism
• mitochondrial communication
• muscle metabolism
• age-related cellular regulation

Researchers often examine MOTS-c in experimental models to better understand how mitochondria-derived peptides may influence cellular adaptation, metabolic stress response, and energy-related gene signaling.

Mechanistic Interest in Research

MOTS-c is commonly investigated for its relationship to AMPK activation, metabolic stress signaling, and mitonuclear communication. Research has suggested that under metabolic stress, MOTS-c may translocate from the mitochondria to the nucleus, where it may influence the expression of genes associated with adaptation and cellular resilience.

Because of this profile, MOTS-c is often selected for research involving nutrient sensing, mitochondrial signaling, glucose handling, and systemic metabolic coordination.

Common Areas of Study

Muscle Metabolism Research

MOTS-c is widely examined in studies involving skeletal muscle metabolism, glucose uptake, and age-related changes in muscular energy handling. It is often selected for models focused on AMPK signaling and muscle homeostasis.

Fat and Energy Regulation

Researchers often study this peptide in laboratory models involving adipose metabolism, insulin sensitivity, lipid utilization, and broader energy-balance pathways.

Metabolic Stress and Gene Regulation

MOTS-c has also been investigated in experimental settings involving cellular stress adaptation, nuclear signaling, and mitochondrial-to-nuclear communication.

Bone and Differentiation Studies

Additional research interest has included osteogenic differentiation, stem cell-related signaling, and pathways associated with bone development and structural maintenance.

Vascular and Endothelial Research

MOTS-c has been explored in models involving endothelial response and vascular function, particularly in relation to metabolic state and AMPK-linked signaling.

Chemical Information

Molecular Formula: C101H152N28O22S2
Molecular Weight: 2174.64 g/mol
Also Known As: Mitochondrial-derived peptide MOTS-c, Mitochondrial open reading frame of the 12S rRNA-c

Research Applications

MOTS-c is commonly selected for laboratory work involving:

• metabolic pathway analysis
• AMPK signaling research
• skeletal muscle metabolism studies
• fat metabolism investigations
• mitochondrial communication models
• age-related cellular function research

Important Notice

For Research Use Only.
This product is intended strictly for laboratory, analytical, and investigational use.

• Not for human consumption
• Not for veterinary use
• Not intended as a drug, food, or dietary supplement
• To be handled only by qualified professionals in controlled research environments